Starting linebacker Eric Kendricks (hamstring) and reserve edge rusher Chris Rumph II (hamstring) also were ruled out.
Star edge rusher Joey Bosa (hamstring) traveled with the team to Nashville and remains questionable for the game. Backup linebacker Daiyan Henley (hamstring) is doubtful.
The Chargers also made two elevations from their practice squad: edge rusher Brevin Allen and safety Dean Marlowe.
This story originally appeared in Los Angeles Times.